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Caudatin induced ubiquitin (Ub)-dependent glucocorticoid receptor (GR) degradation and blocked subsequent Of course-affiliated protein (YAP) nuclear accumulation and target gene transcription signals in BCSCs. These effects present that the GR/YAP signaling pathway regulates BCSC development and that caudatin could possibly be a potential chemoprev

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 7a, b). Though this cavity has progressed to accommodate a charged aa7, its aspect chain is disordered in HsNMT1:MyrCoA:X in contrast to HsNMT1:TI-Y, where by the Ab-loop is disordered along with the substrate aa7 aspect chain interacts with Asp471 (Supplementary Fig. 7d, e). These observations propose that Asp471 initiates aa7 binding while in